糖尿病是否会影响乳腺癌的生存率?
Ross Lawrenson1,2, Chunhuan Lao1, James Stanley3
1Medical Research Centre, The University of Waikato, Hamilton, New Zealand.
Cancer reports (Hoboken, N.J.)
|March 20, 2024
概括
糖尿病对新西兰妇女的乳腺癌生存率没有影响. 观察到的差异与诊断时的年龄和晚期疾病有关,而不是糖尿病本身或治疗变化.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 流行病学 流行病学
背景情况:
- 糖尿病是被诊断为乳腺癌的女性中普遍存在的并发症.
- 了解糖尿病对乳腺癌预后的影响对于个性化治疗策略至关重要.
- 以前的研究对糖尿病和乳腺癌存活率产生了相互矛盾的结果.
研究的目的:
- 为了研究糖尿病和乳腺癌特异性存活率之间的联系,在新西兰.
- 为了确定糖尿病是否影响被诊断患有侵袭性乳腺癌的妇女的死亡风险.
- 确定导致任何观察到的生存差异的因素.
主要方法:
- 一项使用Te Rēhita Mate Ūtaetae-乳腺癌基金会国家注册 (2005-2020) 数据的队列研究.
- 卡普兰-梅尔存活率分析,以比较患有糖尿病和没有糖尿病的女性之间的存活曲线.
- 考克斯的比例危险建模用于估计乳腺癌特定死亡率的危险比率 (HR),调整为混因素.
主要成果:
- 患有糖尿病和没有糖尿病的妇女在5年 (87%对89%) 或10年 (79%对84%) 乳腺癌特异性存活率上没有显著差异.
- 糖尿病妇女乳腺癌特异性死亡率的调整HR为0.99 (95%CI:0.89-1.11).
- 诊断时的晚期癌症阶段和患者年龄是生存差异的主要驱动因素;当分层时,癌症阶段的生存率相似.
结论:
- 糖尿病本身似乎不会独立地影响新西兰队列中的乳腺癌特定存活率.
- 观察到的生存差异主要归因于糖尿病女性中晚期疾病的发病率较高和诊断时的年龄较大.
- 治疗方法在两组之间没有显示出对生存的差异性影响.
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