对于血压的性别差异,需要一个进化保守的嗅觉受体
Jiaojiao Xu1, Rira Choi2, Kunal Gupta1
1Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Science advances
|March 20, 2024
概括
在缺乏嗅觉受体558 (Olfr558) 的小鼠中,血压的性别差异被废除了. 这种受体在调节血压和血管功能方面发挥着关键作用,调节性别特异性影响.
科学领域:
- 生理学 生理学 生理学
- 遗传学 是一个遗传学.
- 心血管科学 心血管科学
背景情况:
- 血压的性别差异得到了充分证实,绝经前妇女通常比男性血压更低.
- 驱动这些基于性别的血压差异的精确生物机制在很大程度上仍然难以捉摸.
- 了解这些差异对于开发有针对性的心血管治疗至关重要.
研究的目的:
- 调查嗅觉受体558 (Olfr558) 在调解血压中的性别差异中的作用.
- 探索Olfr558在心血管系统和脏中的定位和功能.
- 以性别特定的方式检查Olfr558缺乏对血压调节的影响.
主要方法:
- 产生和分析嗅觉受体558敲击 (KO) 鼠.
- 在雄性和雌性KO小鼠中测量血压,脉冲波速度和血管反应能力.
- 在KO小鼠中评估氨酸表达和活性.
- 对人类OR51E1变异的分析,以测量其对透缩血压的性别特异性影响.
主要成果:
- 在Olfr558 KO小鼠中,血压的性别差异不存在.
- 雌性KO小鼠的血压和脉冲波速度增加.
- 雄性KO小鼠表现出降低的宁表达/活性,改变的血管反应能力,并降低了透析压力.
- 一种人类的OR51E1变体显示了与腹压血压的显著性相互作用.
结论:
- 嗅觉受体558 (Olfr558) 在确定血压的性别差异方面发挥着关键作用.
- 这些发现表明,OLFR558/OR51E1在调节性别特异性血压调节方面具有进化保守的功能.
- 针对这种途径可以为性别特异性高血压管理提供新的治疗策略.
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