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Updated: Jun 30, 2025

A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4
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A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4

Published on: March 10, 2018

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JAK/STAT信号通路影响人类CD4+ T细胞中CCR5的表达

Lingyun Wang1, Yunus Yukselten1, Julius Nuwagaba1

  • 1Section of Infectious Diseases, Department of Internal Medicine, Yale University, New Haven, CT, USA.

Science advances
|March 20, 2024
PubMed
概括

用抑制剂向JAK/STAT通路可以降低CD4+T细胞上的CCR5和CCR2表达. 这一发现对于开发针对R5热带艾滋病毒感染的新策略和推进艾滋病毒治愈研究至关重要.

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