保存的免疫结合原子类型预测了对免疫检查点封锁的反应
Jie Mei1,2, Yun Cai3, Rui Xu1,2
1Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, P. R. China.
Cancer communications (London, England)
|March 20, 2024
概括
这项研究基于细胞外矩阵 (ECM) 和免疫细胞活性确定了三种瘤亚型,预测了对免疫检查点阻塞 (ICB) 治疗的反应. "软&热"瘤显示出最好的ICB反应,为癌症治疗提供了新的策略.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 癌症生物学 癌症生物学
背景情况:
- 免疫检查点封锁 (ICB) 已经改变了癌症治疗,但预测患者的反应仍然是一个挑战.
- 细胞外基质 (ECM) 在调节免疫细胞透和抗瘤免疫方面发挥着至关重要的作用.
- 了解ECM和免疫微环境之间的相互作用对于提高ICB疗效至关重要.
研究的目的:
- 开发一种利用ECM特征的创新分类器来预测ICB治疗反应.
- 根据不同的免疫原体亚型,确定新的治疗点.
- 通过根据瘤微环境特征对患者进行分层来提高ICB的有效性.
主要方法:
- 在接受ICB治疗的649名患者中分析了转录体原蛋白活性和免疫特征.
- 使用TCGA和内部数据集 (分别为9,363和1,084个样本) 确定并验证了三种不同的免疫原体亚型.
- 临床前模型被用来研究原在ICB反应中的机械作用.
主要成果:
- 定义了三个亚型:"软&热" (低原蛋白,高免疫),"装甲&冷" (高原蛋白,低免疫),和"安静" (低原蛋白,低免疫).
- "软&热"瘤在癌症类型中表现出对ICB的最强有力的反应;原抑制在临床前模型中增强了ICB的疗效.
- B7-H3被确定为潜在的治疗标,在与预后不佳相关的"装甲和冷"瘤中高度表达.
结论:
- 可通过组织病理学识别的通用免疫结合原子类型可以预测各种癌症的ICB反应.
- 这些亚型为定制个性化免疫治疗策略提供了洞察力.
- 针对ECM-免疫相互作用和B7-H3等特定生物标志物的向可能会改善ICB结果.
相关概念视频
T Cell Activation and Clonal Selection
726
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
726
Cells of the Adaptive Immune Response
985
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
985


