儿童和青少年被诊断患有炎症性肠病,患有可能发生自身免疫病原的疾病的风险增加
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Updated: Jun 30, 2025

Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
Line Riis Jølving1,2, Floor Dijkstra Zegers1, Ken Lund1,2
1Center for Clinical Epidemiology, Odense University Hospital, Odense, Denmark.
患有炎症性肠道疾病 (IBD) 的儿童和青少年面临患有牛皮关节炎和脊椎关节炎等自身免疫疾病的风险增加,通常在IBD诊断的十年内. 其他自身免疫性疾病也显示出高风险.
科学领域:
- 儿科风湿病学 儿科风湿病学
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 炎症性肠病 (IBD) 与成人自身免疫性疾病有关,但关于早期发病IBD的数据有限.
- 了解儿科IBD相关的自身免疫性疾病对于全面的患者护理至关重要.
研究的目的:
- 研究早期IBD诊断和随后的自身免疫相关疾病之间的风险和时间关系.
- 为了确定特定的自身免疫性疾病,其发病率在儿科IBD后增加.
主要方法:
- 丹麦一项全国性的基于登记的队列研究包括从1980年到2021年的儿科IBD患者 (≤18岁).
- 考克斯回归模型分析了与匹配的对照组相比,1/2型糖尿病,乳病,甲状腺疾病,类风湿性关节炎,牛皮性关节炎和脊髓关节炎的风险.
主要成果:
- 这项研究确定了6822名儿科IBD患者和337728名匹配参考.
- 在牛皮关节炎 (HR 4.72),脊椎关节炎 (HR 5.21),腹腔疾病 (HR 2.77),类风湿性关节炎 (HR 2.15) 和1/2型糖尿病 (HR 1.69/1.64) 中观察到显著增加的风险.
- 牛皮关节炎和脊椎关节炎在IBD发病后大约10年表现出来,比其他疾病更早.
结论:
- 儿科IBD显著增加了多种自身免疫性疾病的风险,其中值得注意的例外是甲状腺疾病.
- 牛皮关节炎和脊椎关节炎代表了早期发作的自身免疫并发症,在早期发作的IBD的背景下.
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