在急性呼吸衰竭中测量质量加权的无医院日:修改后的Delphi研究
Catherine L Auriemma1,2,3, Maayra I Butt1, Melanie Bahti1
1Palliative and Advanced Illness Research Center.
Annals of the American Thoracic Society
|March 20, 2024
概括
使用患者报告结果的质量加权无住院日 (HFD) 是可接受的急性呼吸衰竭 (ARF) 研究. 这种方法比标准的HFD更好地捕捉患者的优先事项.
科学领域:
- 关键护理医学 关键护理医学
- 健康 结果 研究 研究 结果
- 患者报告的结果
背景情况:
- 没有住院的日子 (HFD) 是急性呼吸衰竭 (ARF) 和危急疾病研究的常见终点.
- 目前的HFD措施没有捕捉到对幸存者和家人重要的功能状态或生活质量.
- 在重症监护研究中,需要以患者为中心的结果措施.
研究的目的:
- 开发一种可接受的方法来测量质量加权的HFD.
- 将患者报告的结果纳入HFD计算.
- 在专家中评估质量权衡方法的可接受性.
主要方法:
- 在57名ARF专家的帮助下,使用了四轮修改后的Delphi过程.
- 专家评价了幸存者领域,数据收集方法和质量权重方法.
- 共识被定义为70%的评价一个项目是可接受的,而15%的评价是不可接受的.
主要成果:
- 身体功能和与健康有关的生活质量是优先考虑的生存领域.
- 在数据收集持续时间 (<15分钟),代孕完成和24个月的随访方面达成了共识.
- 在EuroQol-5维度 (EQ-5D) 调查问卷中,对于高频器的质量权重达到了共识.
结论:
- 使用EQ-5D的质量加权HFD对于ARF研究的利益相关者来说是可以接受的.
- 这种方法比未加权的HFD更有效地捕捉患者和家庭的优先事项.
- 专家们更喜欢质量加权的HFD,而不是未加权的HFD或生存作为研究终点.
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