在哺乳动物中化过的Metaviral Capsid基因的不同进化史
William S Henriques1, Janet M Young2, Artem Nemudryi1
1Department of Microbiology and Cell Biology, Montana State University, Bozeman, MT 59717, USA.
Molecular biology and evolution
|March 20, 2024
概括
主体基因组可以重新利用自私的遗传元素. 这项研究揭示了Metaviridae反转移体的至少五个独立化事件,在哺乳动物中产生了新的功能基因.
科学领域:
- 基因组学就是基因组学.
- 进化生物学 进化生物学
- 分子生物学分子生物学
背景情况:
- 自私的遗传元素,如逆转移体,构成了哺乳动物基因组的重要组成部分.
- 偶尔,宿主基因组会整合和功能化这些元素的部分.
研究的目的:
- 研究从Metaviridae的逆转移体中化的体 (CA) 基因的进化路径和功能能力.
- 为了确定这些古代养基因的进化历史的新见解.
主要方法:
- 对完整的人类基因组组合和其他25种脊椎动物基因组的分析.
- 重新分析了养的Metaviridae CA基因的进化轨迹和功能潜力.
主要成果:
- 从不同的Metaviridae中识别出至少五个独立的化事件.
- 在净化选择下发现了三种普遍保留的单拷贝基因和两个胎盘哺乳动物特异性基因家族.
- 发现了多样化的氨基终端域,在RTL10中丧失编码能力,在RTL3中使用差异编程核糖体移,并在PNMA家族中保留了RNA结合域 (RBD).
- 纠正了CCDC8基因的注释,并在现存的Metaviridae中确定了RBD,揭示了新的逆转移素域配置.
结论:
- 从Metaviridae的多个独立的化事件发生在胎盘哺乳动物的共同祖先中.
- 这些事件导致了不同的进化结果,包括普遍保留的基因和具有不同功能领域和进化动态的哺乳动物特异性基因家族.
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