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新型白醇智能脂质;抗癌活性的设计,配方和生物评估

Reem Fekry Diab¹, Tamer M Abdelghany^2,3, Shadeed Gad⁴

¹Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Heliopolis University, Cairo 11757, Egypt.

The Journal of pharmacy and pharmacology

|March 20, 2024

概括

这项研究开发了智能脂质纳米载体,以改善复星 (RES) 的抗癌作用. 这种新型配方显著增强了RES吸收和细胞积累,提高了其对抗癌细胞的治疗潜力.

科学领域:

纳米技术纳米技术
制药科学制药科学
在瘤学瘤学.

背景情况:

复星 (RES) 具有强大的抗癌性质,但其生物可用性较差.
限制包括快速吸收,低口服生物可用性和水溶性差.
药物载体对于增强 RES 治疗应用至关重要.

研究的目的:

为了增强复星 (RES) 的抗癌活性.
为了将可再生能源制成一种新的纳米载体,智能脂质.
为了克服 RES 在口服吸收和生物可用性的局限性.

主要方法:

用RES装载的智能脂质使用高剪切热均质化方法制备.
一个21 × 32的因数设计优化了脂质和表面活性剂度.
特性包括粒子大小,泽塔潜力,捕获效率,TEM,DSC和FTIR.

主要成果:

优化的可再生能源装载智能脂质呈现出小颗粒尺寸 (288.63 nm),良好的泽塔电位 (-16.44 mV) 和高捕获效率 (86.346%).
传输电子显微镜证实了没有融合的球形粒子.
该配方显示持续释放和显著增强对MCF7,HepG2和HT29癌细胞系的细胞毒性活性,降低IC50值.
流细胞计和附件V测定显示细胞循环停止和亡诱导.

结论:

将可再生能源装入智能脂质纳米载体,改善了其吸收和细胞积累.
新的纳米载体配方显著增强了RES的抗癌特性.
智能脂质代表了提高复星的治疗疗效的有希望的策略.

关键词:

抗癌性质抗癌性质细胞系细胞系的细胞系.高剪切热均化高剪切热均化复星醇是一种复星醇.智能脂质是一种智能脂质.第三代的第三代人.

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