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Updated: Jun 30, 2025

Assaying Protein Kinase Activity with Radiolabeled ATP
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在BTK中,SH3域中的化Y223反映了催化活性,但没有影响生物功能

H Yesid Estupiñán1,2, Thibault Bouderlique1, Chenfei He3

  • 1Department of Laboratory Medicine, Karolinska Institutet, Huddinge, Sweden.

Blood advances
|March 20, 2024
PubMed
概括

在布鲁顿的氨酸激酶 (BTK) 中对氨酸223 (Y223) 的酸化对于B细胞功能来说并不必不可少. 这一发现挑战了长期以来关于BTK的酶活性和B细胞存活机制的假设.

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