相关实验视频
Updated: Jun 30, 2025

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
在成年人发病的免疫缺陷中,抗介素-23自身抗体
Aristine Cheng1, Anuj Kashyap1, Helene Salvator1
1From the Division of Intramural Research, National Institute of Allergy and Infectious Diseases (A.C., A.K., H.S., L.B.R., D.C., L.D., J.M.R., B.E.M., A.F.F., S.K.B., A.P.H., A.Z., I.S., C.S.Z., M.S.L., S.M.H.), and the Thoracic and GI Malignancies Branch, Center for Cancer Research, National Cancer Institute (M.B., A.R.), National Institutes of Health, Bethesda, MD; the Division of Infectious Diseases, Department of Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan (A.C.); the Department of Respiratory Medicine, Hôpital Foch, Unité Mixte de Recherche 0892, Virology and Molecular Immunology Laboratory, Suresnes Paris-Saclay University, Suresnes, France (H.S.); Indiana University Melvin and Bren Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis (F.A.-L., P.J.L.); Immune Deficiencies Laboratory, National Institute of Pediatrics, Mexico City (S.O.L.R.); and the Department of Immunology, Repatriation General Hospital Concord, University of Sydney, Concord, NSW, Australia (S.R.).
对交叉蛋白-23 (抗交叉蛋白-23) 的自身抗体与患有胸腺瘤的患者的严重机会性感染有关. 中和抗-23活性与感染严重程度相关,突出其在免疫防御中的作用.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 对白素-12 (抗白素-12) 的自身抗体在胸腺瘤患者中很常见.
- 机会性感染仅发生在这些患者的一小部分.
- 洲际蛋白-12和洲际蛋白-23共享一个共同的子单元 (p40).
研究的目的:
- 在患有胸腺瘤和机会性感染的患者中研究抗素-23 (抗素-23) 自身抗体的作用.
- 确定是否与感染的严重程度和类型有关.
主要方法:
- 被查的患者用抗流素-12对抗流素-23.
- 测试了胸腺瘤患者和患有异常感染的患者的验证队列.
- 评估了自身抗体的中和活性,并与感染状态相关联.
主要成果:
- 50%的患有抗联素-12和严重感染的患者也有中和抗联素-23.
- 在81%的胸腺瘤患者中,抗干乐素-23的存在与感染状况有关.
- 在26%的胸腺瘤患者和83%的扩散性感染患者中检测到中和性抗干白素-23.
结论:
- 中和抗-23与严重的,持久的机会性感染有关.
- 这一发现表明,互白素-23在防御某些病原体方面起着关键作用.
- 需要进一步的研究,以了解抗干白素-23在免疫受损个体的临床影响.
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