多发性硬化症患者的喘和慢性阻塞性肺病 (COPD):系统性审查和元分析
Hamed Ghoshouni1, Nazanin Rafiei2, Mohammad Yazdan Panah3
1Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Multiple sclerosis and related disorders
|March 20, 2024
概括
多发性硬化症 (MS) 会增加患慢性阻塞性肺病 (COPD) 的风险. 然而,MS与喘没有显著的联系. 早期识别患有呼吸系统风险的MS患者对于及时干预至关重要.
科学领域:
- 神经学 神经学
- 肺部病理学 肺部病理学
- 流行病学 流行病学
背景情况:
- 众所周知,多发性硬化症 (MS) 影响了喘和慢性阻塞性肺病 (COPD) 等呼吸系统疾病的发病和进展.
- 了解MS患者中这些呼吸道疾病的患病率和风险对于全面的患者护理至关重要.
研究的目的:
- 系统地审查和综合现有关于pwMS中喘和COPD的流行率和几率的文献.
- 量化MS与患喘或COPD的可能性之间的关联.
主要方法:
- 在主要的科学数据库 (PubMed,Embase,Scopus,Web of Science) 进行了全面的系统搜索,直到2023年5月.
- 采用随机效应模型,使用R软件计算pwMS中喘和COPD的95%置信区间 (CI) 的聚合流行率和几率比率 (OR).
主要成果:
- 该审查包括了40项研究,包括287,702 pwMS.
- 在pwMS中喘和COPD的综合流行率分别为5.97%和3.03%.
- 虽然喘在MS中没有显著的几率 (OR=1.14,p=0.53),但COPD风险显著增加 (OR=1.28,p<0.01).
结论:
- 这些发现表明,多发性硬化与患上COPD的风险增加有关,但不与喘有关.
- 这凸显了对患有多发性硬化症的个体进行主动呼吸系统健康监测的需要.
- 识别患有呼吸道并发症风险较高的pwMS可以促进有针对性的预防策略和管理.
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