肺囊 jirovecii 肺炎二次到布林托马布治疗:一个案例报告
Yue Yin1, Kaini Shen2, Hanyu Li3
1Division of General Internal Medicine, Department of Primary Care and Family Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, State Key Laboratory of Complex Severe and Rare Diseases, Beijing, China.
Chemotherapy
|March 20, 2024
概括
肺炎 (PCP) 是在B细胞前体急性淋巴细胞白血病 (ALL) 治疗中的罕见但严重的不良反应. 早期识别和及时治疗对于患者的康复至关重要.
科学领域:
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 布利纳图马布越来越多地用于复发/耐药B细胞前体急性淋巴细胞白血病 (ALL),包括MRD阳性病例.
- 人们越来越多地认识到布利纳图马布的不良影响.
- 肺囊炎 (Pneumocystis jirovecii) 肺炎 (PCP) 是一种罕见的并发症,与blinatumomab治疗有关.
研究的目的:
- 在接受布利纳图马布治疗的患者中报告PCP病例.
- 在这种情况下,要突出PCP的早期发病和快速进展.
- 强调在布利纳马布治疗期间对PCP保持警的重要性.
主要方法:
- 一个案例介绍的是一个70岁的女性,患有费城样CRLF2过度表达B细胞ALL.
- 患者接受了布利纳图马布作为整合疗法.
- 通过下一代测序证实了PCP的诊断,尽管有经验预防.
主要成果:
- 患者在布利纳马布治疗时发烧和呼吸衰竭.
- 胸部CT显示了特有的透和不透明.
- 在周围血液中检测到Pneumocystis jirovecii.
- 用高剂量的三甲胺-硫甲醇和德克萨米他治疗导致完全康复.
结论:
- 与blinatumomab治疗相关的PCP很少见,但可能有早期发病和快速进展.
- 预防可能并不总是可以预防PCP感染.
- 当施用blinatumomab时,需要提高临床注意力.
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