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Updated: Jun 30, 2025

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视神经头部微循环的评估在一个单侧视野缺陷的开角玻璃眼患者

Pei-Wen Lin^1,2, Li-Wen Chiu¹

¹Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.

Ophthalmic research

|March 20, 2024

概括

在开放角眼患者的视神经头部的微循环.

科学领域:

眼科医生眼科眼科
玻璃眼研究研究玻璃眼研究
微循环研究微循环研究

背景情况:

带有单边视野 (VF) 损失的开放角眼镜 (OAG) 对理解视神经头部 (ONH) 微循环提出了独特的挑战.
在OAG患者中,周边不受影响的眼睛的微循环状态仍未得到充分研究.

研究的目的:

在OAG患者中调查ONH微循环,患者有单边VF损失.
为了比较受影响的眼睛,不受影响的眼睛和健康对照之间的微循环和结构参数.

主要方法:

使用激光光斑流图 (LSFG) 进行ONH微循环测量 (MA,MV,MT).
采用光谱域光学连贯性断层扫描 (SD-OCT) 检测圆状视网膜神经纤维层 (cpRNFL) 厚度和斑点厚度.
分析了38名OAG患者和31名健康对照者的数据,包括使用接收器操作特征曲线 (AROCs) 下的区域的诊断准确性.

主要成果:

没有受到影响的眼睛表现出比受影响的眼睛更高的cpRNFL和斑点厚度,但低于健康的眼睛.
视神经头部微循环 (MA,MV) 在健康和不受影响的眼睛中明显高于受影响的眼睛.
没有受影响的眼睛的组织面积 (MT) 位于受影响的OAG眼睛和健康眼睛之间的中间位置.

结论:

在单边VF损失的OAG患者周边不受影响的眼睛中,ONH微循环减少.
在可检测的VF损伤之前,LSFG可以检测高风险眼睛的ONH变化.
这些发现表明,血管病理生理学在青光眼的发展中起着作用.

关键词:

激光光斑的流动格拉希yyy.视角开放的玻璃眼 (Open-angle glaucoma) 是一种视角开放的玻璃眼.光谱域光学连贯性断层扫描.单边视野损失单边视野损失

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