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Updated: Jun 30, 2025

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
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Published on: June 21, 2018

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综合性多基因风险评分提高了复杂特征和疾病的预测准确度

Buu Truong1, Leland E Hull2, Yunfeng Ruan1

  • 1Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, 415 Main St, Cambridge, MA 02142, USA; Center for Genomic Medicine and Cardiovascular Research Center, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.

Cell genomics
|March 20, 2024
PubMed
概括

新的多基因风险评分 (PRS) 框架,PRSmix和PRSmix+,通过利用PRS数据和基因相关性特征来提高疾病和特征的预测准确性. 这些方法在各种祖先中显示出显著的改进.

关键词:
在PRS中使用PRS.南亚地区的南亚人.临床实用性的临床实用性组合 组合 组合 组合 组合交叉祖先的祖先交叉祖先的祖先整合性的整合性的整合.

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