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调整分子运动增强片两性纳米纤维中的内在光

Natchayaporn Sindhurattavej¹, Shreya Jampana², Mai Phuong Pham²

¹Department of Chemistry, Harvey Mudd College, Claremont, California 91711, United States.

Biomacromolecules

|March 20, 2024

概括

具有特定氨基酸序列的两性 (PAs) 在自组成纳米纤维时表现出增强的聚合诱导排放 (AIE). 战略分子设计和温度控制显著提高了先进应用的AIE.

科学领域:

超分子化学超分子化学
材料科学材料科学材料科学
生物物理学的生物物理.

背景情况:

两性 (PAs) 是众所周知的多功能分子,可以自组装成纳米纤维.
最近的发现表明PAs可以表现出聚合诱导排放 (AIE).
在纳米纤维内调整PA分子运动是增强AIE的关键.

研究的目的:

通过分子运动控制来加强AIE的战略设计PA.
调查氨基酸序列和包装对AIE的影响.
探索PA纳米纤维中AIE的温度影响.

主要方法:

系统地修改PA的疏水核附近的氨基酸序列.
合成和自组装六种不同的PA设计.
描述AIE属性,包括量子产量和光强度.
对PA纳米纤维光和二次结构的温度依赖性研究.

主要成果:

该PA设计C16VVAAK2显示了最高的量子产量 (0.17),比其他设计增加了10倍以上.
精确的氨基酸放置,特别是核心附近的VVAA,显著增强了刚性和AIE.
温度从5°C上升到65°C,导致C16VVAAK2.2的光强度增加了4倍.
温度诱导的从β板转变为随机的线圈结构与增强的能量转移相关.

结论:

战略分子设计的PA可以创建高度光的AIE系统.
氨基酸在疏水核附近的紧密包装和刚性对于高AIE至关重要.
温度调节提供了一个额外的途径来增强PA纳米纤维中的AIE.
这项工作为设计具有可调节光物理性质的自组装系统提供了洞察力.

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