唾液培养转化与腔内菌菌群 (Mycobacterium avium) 复杂肺部疾病中的死亡率之间的关联
Ju Kwang Lee1, Seonok Kim2, Yong Pil Chong3
1Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.
Chest
|March 20, 2024
概括
实现培养转化显著降低了患有空腔病变的Mycobacterium avium复杂肺病 (MAC-PD) 患者的死亡率. 缺乏转换与死亡风险大幅增加有关.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 临床医学 临床医学
背景情况:
- 对于患有Mycobacterium avium复杂性肺病 (MAC-PD) 和腔腔病变的患者,关于治疗结果的预后仍然不清楚.
- 这项研究调查了实现唾液培养转换对该患者群体死亡率的影响.
研究的目的:
- 确定腔MAC-PD患者的唾液培养转化是否与预后改善有关.
- 评估洞腔MAC-PD患者治疗结果和死亡率之间的关系.
主要方法:
- 从2002年至2020年,对351名患有洞腔MAC-PD的患者进行了回顾性分析,这些患者接受了含有宏化物的治疗方案 (≥6个月).
- 基于治疗结束时的唾液培养转换的全因死亡率分析.
- 包括MAC-PD的纤维腔体和腔体结节性支气管类型.
主要成果:
- 69.8%的患者实现了培养转化.
- 在实现培养转换的患者中,全因死亡率显著降低 (5.3%对35.8%,P < .001).
- 缺乏培养转换是较高死亡率的重要预测因素 (调整后危险比率,5.73).
结论:
- 腔MAC-PD患者没有实现培养转化,死亡率明显高.
- 唾液培养转化是治疗成功和腔MAC-PD中改善生存率的关键指标.
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