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含有梅纳的体向固体脂质纳米颗粒的抗癌和化学敏感作用

Mohamed Zoughaib¹, Tatiana N Pashirova², Viktoriia Nikolaeva¹

¹Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlyovskaya St., 420008 Kazan, Russia; Scientific and Educational Center of Pharmaceutics, Kazan Federal University, 18 Kremlyovskaya St., 420008 Kazan, Russia.

Journal of pharmaceutical sciences

|March 20, 2024

概括

这项研究开发了载有梅纳 (MD) 的向固体脂质纳米颗粒 (SLN),以增强抗癌疗法. 经RGD修改的MD-SLN配方改善了MD的MD.

科学领域:

纳米医学是一种纳米医学.
生物技术是生物技术.
癌症治疗癌症治疗

背景情况:

梅纳迪 (MD) 是癌症治疗中一个有前途的氧化还原调节剂.
在化物向纳米载体中MD的细胞活性仍未得到充分探索.
固体脂质纳米粒子 (SLN) 为药物输送提供了一个潜在的平台.

研究的目的:

开发和表征MD载SLN修饰与细胞外矩阵 (ECM) 衍生.
研究RGD度对SLN特征和细胞吸收的影响.
评估针对性的MD-SLN配方增强的抗癌疗效.

主要方法:

用MD装载的SLN的配方.
通过RGD来修改SLN.
动态光散射 (DLS) 用于纳米粒子的表征.
评估细胞吸收,氧化剂,减少GSH和细胞毒性活动.
评估使用多克索鲁比辛和西斯普拉丁的化学敏感化作用.

主要成果:

针对SLN,优化RGD脂比率被确定为SLN.
装有MD的SLN保持了纳米粒子的完整性,并保护MD免受谷氨结合.
经RGD修改的MD-SLN在PC-3细胞中表现出增强的细胞积累,氧化剂,减少GSH和细胞毒性作用.
该配方使PC-3和OVCAR-4癌细胞对常规化疗药物敏感.

结论:

针对的MD-SLN配方代表了增强抗癌疗法的有希望的策略.
这种方法改善了梅纳迪翁的药理动力学特征和疗效.
用向的MD-SLN和常规药物的联合治疗有可能改善癌症治疗结果.

关键词:

癌细胞癌细胞癌细胞化学敏感化剂是一种化学敏感化剂.西斯普拉丁 (Cisplatin) 是一种德克索鲁比辛是一种多克索鲁比辛.谷氨缺乏症谷氨缺乏症梅纳迪翁 (Menadione) 是一种可靠的药物.固体脂质纳米粒子固体脂质纳米粒子针对性酸的目标.

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