皮莫本丹有控制释放的瓜尔打印:为个性化兽医药物量化药物剂量
Júlia Leão1, Valeria Luiza Winck2, Cesar Liberato Petzhold3
1Programa de Pós-Graduação Em Ciências Farmacêuticas, Faculdade de Farmácia Universidade Federal do Rio Grande do Sul, Avenida Ipiranga, 2752, Porto Alegre, Rio Grande do Sul 90610-000, Brazil; Laboratório de Nanocarreadores e Impressão 3D Em Tecnologia Farmacêutica (Nano3D), Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brasil.
International journal of pharmaceutics
|March 20, 2024
概括
三维 (3D) 打印为狗心脏病治疗提供了一种新的解决方案. 这项研究开发了3D打印的皮莫本丹 (PBD) 片,使用瓜尔进行定制剂量和受控释放.
科学领域:
- 兽医药理学 兽医药理学
- 材料科学 材料科学 材料科学
- 制药技术 制药技术 制药技术
背景情况:
- 狗的慢性心脏病治疗因药物剂量变化和现有皮莫本丹 (PBD) 配方的不方便管理而复杂化.
- 目前的PBD可片很大,需要每天服用两次,这给有效的兽医治疗带来了挑战.
研究的目的:
- 开发定制的,按需3D打印的皮莫本丹 (PBD) 配方,用于治疗犬类心脏病.
- 评估自然聚合物 (瓜尔和桑坦) 在控制释放PBD打印机的3D打印油墨中的使用.
- 评估印刷品的形状和尺寸对药物释放概况的影响.
主要方法:
- 使用半固体挤出3D打印设计和制造的受控释放,调味的PBD打印机.
- 作为印刷油墨的主要组成部分,研究了 guar gum 和 xanthan gum,评估了其质性和可打印性.
- 制作了各种形状和尺寸的印刷品,以实现个性化的PBD剂量调整.
主要成果:
- 与用于3D打印应用的香草相比,香草表现出优越的质行为和可打印性.
- 通过3D打印的瓜尔印花显示了PBD的可控释放特征,无论其尺寸如何.
- 该研究成功地通过使用天然聚合物进行3D打印,创建了可定制的PBD剂量形式.
结论:
- 瓜尔是一种合适的天然聚合物,用于开发3D打印,控制释放的PBD配方,用于兽医.
- 通过3D打印,可以量身定制PBD剂量和改善药物输送,用于治疗犬类心脏病.
- 这项研究为兽医应用中先进的,针对患者的药物解决方案铺平了道路.
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