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布申配方通过调节Tfh细胞和B细胞子集来促进CHB患者HBsAg水平的降低.

Longshan Ji1, Jinghan Wei1, Rongjie Zhang1

  • 1Laboratory of Cellular Immunity, Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Key Laboratory of Liver and Kidney Diseases (Shanghai University of Traditional Chinese Medicine), Ministry of Education, Shanghai, 201203, China.

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概括

布申配方 (BSF) 提高了慢性乙型肝炎 (CHB) 治疗结果,特别是在以前用Peg-IFN-α治疗的患者中. 这种传统中医药通过通过IL-21/IL-21R通路促进Tfh和B细胞相互作用来调节免疫反应.

关键词:
在B细胞中,B细胞是布申的公式是布申的公式.慢性乙型肝炎 慢性乙型肝炎毛囊辅助T细胞 毛囊辅助T细胞这就是HBsAg.

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科学领域:

  • 免疫学 免疫学 免疫学
  • 药理学 药理学是指药理学的学科.
  • 肝病学 肝病学是一种肝病学.

背景情况:

  • 布申配方 (BSF) 是一种有效的传统中医药 (TCM) 治疗慢性乙型肝炎 (CHB).
  • 之前的研究强调了BSF的有效性,但其在不同CHB阶段和免疫调节机制的有效性需要进一步调查.

研究的目的:

  • 为了比较BSF在未接受治疗和接受Peg-IFN-α治疗的CHB患者中的治疗效果.
  • 探索BSF在CHB治疗中的潜在免疫调节机制.

主要方法:

  • 一项对266名CHB患者的回顾性研究,这些患者接受了BSF加Peg-IFN-α或Peg-IFN-α单疗法.
  • 对血清HBV标记物,HBVDNA,ALT/AST,TCM症状,外围毛囊辅助T细胞 (Tfh) 和B细胞亚型的分析.
  • 生物信息学分析和体外共同培养系统被用来研究免疫调节机制.

主要成果:

  • 与Peg-IFN-α结合的BSF显著改善了HBsAg下降和HBeAg血清率,与Peg-IFN-α单疗相比,特别是在之前接受治疗的患者中.
  • BSF治疗增加了Tfh细胞频率和IL-21水平,并增强了B细胞上的IL-21R表达.
  • 实验室研究表明,降低了HBsAg和HBeAg水平,并调节了Tfh和B细胞群.

结论:

  • BSF在改善CHB的血清标记方面表现出卓越的疗效,特别是在接受Peg-IFN-α治疗的患者中.
  • BSF的免疫调节机制涉及通过IL-21/IL-21R信号通路增强Tfh和B细胞相互作用.