沿着微生物群-肠-大脑轴:使用植物多糖类来改善精神障碍
Jiayu Gao1, Ying Liang2, Pu Liu1
1School of Chemical Engineering and Pharmaceutics, Henan University of Science & Technology, Luoyang, China.
International journal of biological macromolecules
|March 20, 2024
概括
植物多糖可以通过调节肠道微生物群和肠-大脑轴来改善精神障碍. 像葡萄糖这样的关键成分显示出潜力,但针对性治疗需要更多的研究.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 对于精神疾病,肠道微生物群的干预正在出现.
- 植物多糖与肠道微生物群相互作用,影响健康.
- 微生物群-肠-大脑轴对心理健康至关重要.
研究的目的:
- 通过微生物群-肠-大脑轴,审查植物多糖在精神障碍中的作用.
- 总结化学特性,代谢物和作用机制.
- 确定关键的结构组成部分和未来的研究方向.
主要方法:
- 关于植物多糖,肠道微生物群和精神疾病的研究的文献综述.
- 对相关植物多糖的化学结构和代谢物的分析.
- 检查沿着微生物群-肠-大脑轴的机制.
主要成果:
- 植物多糖和代谢物可以通过发酵重塑肠道微生物群.
- 机制包括神经递质调节,减少炎症 (NLRP3 / NF-κB通路),减少神经元亡,增强抗氧化活性.
- 单糖糖和 -4-α-Glcp-(1→结构被确定为有力的成分.
结论:
- 植物多糖体通过向微生物群-肠道-大脑轴,显示出管理精神障碍的巨大潜力.
- 需要进一步的研究来探索结构-活动关系,安全性,并进行人体试验.
- 基于植物多糖的产品的开发需要机械和临床验证.
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