炎症与重症监护后综合征之间的关联:系统性审查
C Docherty1, C Page2, J Wilson3
1Academic Unit of Anaesthesia, Critical Care and Peri-operative Medicine, School of Medicine, Dentistry and Nursing, University of Glasgow, Glasgow, UK.
Anaesthesia
|March 20, 2024
概括
炎症可能与危急疾病后的长期症状有关,但证据是混合的. 需要更多的研究来了解重症监护室幸存者的炎症概况及其对康复的影响.
科学领域:
- 关键护理医学 关键护理医学
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
背景情况:
- 后重症监护综合征 (PICS) 涵盖了严重疾病后持续的身体,认知和情绪缺陷.
- 在PICS背后的病理机制仍然不太清楚.
- 本综述研究了严重疾病幸存者的炎症和PICS特征之间的联系.
研究的目的:
- 系统地审查和综合现有证据,关于炎症和PICS特征之间的关联在重症幸存者.
- 确定特定的炎症生物标志物,这些生物标志物可能与PICS的长期结果有关.
主要方法:
- 系统地搜索相关数据库的文献,以研究患有严重疾病的人类参与者.
- 包括报告炎症相关生物标志物和PICS结果措施的研究.
- 分析了32项研究,包括一次初级分析 (23项研究) 和一个脑损伤子组 (9项研究).
主要成果:
- 在包括的研究中,评估了47种生物标志物和44种结果措施的广泛范围.
- 干白素-8,C反应蛋白和干白素-10在超过60%的研究中经常与PICS结果有关.
- 在生物标志物选择,采样时间点和结果报告方面存在显著的变化.
结论:
- 关于炎症和长期PICS结果之间的直接关联的证据是混合的.
- 需要进一步进行高质量的研究,以确定幸存者的纵向炎症概况.
- 纵向研究对于评估炎症对重症恢复的影响至关重要.
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