使用非离子糖表面活性剂开发一种含有奥拉普丁的皮肤透射配方
Kathrine Anne Flores1,2, Akie Okada1, Florencio Arce2,3
1Graduate School of Pharmaceutical Sciences, Josai University.
Chemical & pharmaceutical bulletin
|March 20, 2024
概括
糖增强了通过皮肤传递的auraptene (Aur),一种具有低皮肤透度的治疗化合物. 分散型配方,特别是含有糖果棕酸盐的配方,改善了Aur的皮肤透和保留.
科学领域:
- 药理学 药理学是指药理学的学科.
- 材料科学 材料科学 材料科学
- 皮肤病学 皮肤病学
背景情况:
- 奥拉普丁 (Aur) 是一种具有治疗效益但穿透皮肤较差的天然化合物,限制其局部应用.
- 寻求通过皮肤递送药物系统来克服Aur的低脂性和皮肤屏障挑战.
- 非离子糖 (SE) 是生物相容的辅助剂,有可能增强具有挑战性的分子的输送.
研究的目的:
- 调查新型糖 (SE) 在改善auraptene (Aur) 通过皮肤浸透和皮肤分布方面的疗效.
- 开发和表征凝和分散类型的配方用于Aur的交付使用各种SEs.
- 评估通过基于SE的配方提供的Aur的皮肤透和保留特征.
主要方法:
- 制备含有Aur和不同SEs的凝和分散型配方.
- 在配方中的Aur捕获效率的量化.
- 使用老鼠皮肤的弗朗茨扩散细胞评估Aur皮肤透和沉积.
- 基于SE的配方与控制配方的比较.
主要成果:
- 与凝类型配方相比,分散型配方显示出更高的 Aur 捕获效率.
- 基于SE的分散配方显著增强了8小时的Aur皮肤透和保留.
- 含有糖棕酸盐 (sSP) 的配方显示出Aur的皮肤透率最高.
- 随着分散型配方的使用,在全厚皮肤中观察到Aur度的增加.
结论:
- 糖,特别是在分散型配方中,有效地增强了通过皮肤传递的奥拉 (Aur).
- 苏克罗斯棕酸盐显示为改善Aur的皮肤透和保留的辅助剂.
- 开发的基于SE的配方有可能用于药物和化品应用,需要有效的通过皮肤输送.
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