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相关概念视频

Tumor Immunotherapy01:27

Tumor Immunotherapy

524
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
524
Cancer Therapies02:49

Cancer Therapies

7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.6K
Cancer Vaccines01:30

Cancer Vaccines

365
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
365
The Tumor Microenvironment02:17

The Tumor Microenvironment

6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K

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相关实验视频

Updated: Jun 30, 2025

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
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Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

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免疫疗法和放射疗法组合治疗肉瘤

Qian S Zhang1, John P Hayes1, Vinai Gondi1

  • 1Department of Radiation Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL.

Seminars in radiation oncology
|March 20, 2024
PubMed
概括

将放射疗法与免疫疗法相结合,为改善晚期肉瘤患者的生存结果提供了一个有希望的策略. 进一步研究最佳时间,剂量和分量对于最大限度地提高治疗效益至关重要.

科学领域:

  • 在瘤学瘤学.
  • 辐射瘤学 辐射瘤学
  • 免疫治疗是一种免疫疗法.

背景情况:

  • 肉瘤是一种罕见且多样化的癌症,在晚期的癌症中存活率较低.
  • 放射治疗是局部化和转移性肉瘤的标准治疗方法.
  • 将放射疗法与免疫疗法结合起来是一种新的方法,可以提高治疗效率.

研究的目的:

  • 为了审查瘤免疫微环境在肉瘤.
  • 为了探索放射治疗的免疫调节作用.
  • 讨论放射疗法和免疫疗法在肉瘤治疗中的结合.

主要方法:

  • 临床前和临床研究的文献综述.
  • 对瘤免疫微环境多样性的分析.
  • 评估放射治疗对瘤免疫微环境的影响.
  • 对调查放射治疗和免疫治疗组合的临床试验的审查.

主要成果:

  • 放射治疗可以调节瘤的免疫微环境,可能使瘤对免疫治疗敏感.
  • 放射治疗与免疫治疗结合的最佳时间,剂量和分量需要进一步调查.
  • 已完成和正在进行的临床试验正在探索这些组合用于肉瘤治疗.

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Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
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相关实验视频

Last Updated: Jun 30, 2025

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
07:29

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

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Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
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Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

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Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
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Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

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结论:

  • 将放射疗法与免疫疗法相结合具有显著的潜力,可以改善肉瘤治疗结果.
  • 了解肉瘤瘤免疫微环境和放射治疗的免疫调节作用是关键.
  • 未来的研究应该专注于优化组合策略和评估临床试验数据.