酒精消费和所有原因和特定原因死亡的风险 - 一个线性和非线性门德尔随机化研究
Nigussie Assefa Kassaw1,2,3,4, Ang Zhou1,2,4,5, Anwar Mulugeta1,2,4,6
1Australian Centre for Precision Health, University of South Australia, Adelaide, Australia.
International journal of epidemiology
|March 20, 2024
概括
这项遗传研究发现,高饮酒量线性增加过早死亡风险. 与一些观察性研究相反,即使在适度摄入水平下也没有观察到任何保护性益处.
科学领域:
- 遗传学 是一个遗传学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 观察性研究表明,轻度至中度的酒精摄入量可以防止过早死亡.
- 这项研究采用了基因方法来研究酒精消费和死亡率之间的关系.
- 这项研究旨在澄清酒精摄入量与因特定原因死亡率之间的线性和非线性关联.
研究的目的:
- 用遗传方法评估酒精消费与死亡率之间的关系.
- 要确定酒精摄入量与死亡率之间的关联是线性的还是非线性的.
- 评估酒精消费对各种原因死亡率的影响.
主要方法:
- 利用了来自278,093名英国生物库参与者的数据 (年龄在37-73岁之间).
- 采用孟德尔随机化 (MR) 用94个基因变异来衡量习惯性饮酒.
- 使用五种方法进行线性MR分析,使用双排列方法进行非线性MR分析.
主要成果:
- MR 分析显示,酒精消费与过早死亡之间存在正线性关联.
- 增加的酒精摄入与较高的死亡率相关:所有原因 (OR 1.27),心血管 (OR 1.30),癌症 (OR 1.20) 和消化系统疾病 (OR 2.06).
- 没有发现呼吸道疾病或COVID-19死亡率的显著关联;没有证据表明J形曲线或较低摄入水平的保护作用.
结论:
- 基因预测较高的酒精消费与增加的过早死亡风险密切相关.
- 该研究没有发现证据支持适度饮酒的保护性益处.
- 这些发现挑战了之前的观察数据,这些数据表明适度饮酒对健康有潜在的益处.
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