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Updated: Jun 18, 2026

Solid Phase Synthesis of a Functionalized Bis-Peptide Using "Safety Catch" Methodology
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Published on: May 15, 2012

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工艺质量强度 (PMI):对当前制造工艺的整体分析,为合成的可持续性提供信息

Ivy Kekessie1, Katarzyna Wegner2, Isamir Martinez3

  • 1Early Discovery Biochemistry - Peptide Therapeutics, Genentech, Inc., A Member of the Roche Group, 1 DNA Way, South San Francisco, California 94080, United States.

The Journal of organic chemistry
|March 20, 2024
PubMed
概括

治疗性制造,主要使用固相合成 (SPPS),具有很高的环境影响,工艺质量强度 (PMI) 约为13,000. 这项研究评估了40个过程的PMI,揭示了对更绿色合成方法的需求.

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