与普通人群相比,囊性纤维化患者的COVID-19:严重程度和病毒与宿主细胞相互作用
Fabiana Ciciriello1, Francesco Panariello2, Paola Medino3
1Cystic Fibrosis Center, 'Bambino Gesù' Children's Hospital, IRCCS, Rome, Italy.
概括
囊性纤维化 (CF) 患者可能不会经历更严重的COVID-19由于较低的核糖体基因表达,可能阻碍病毒复制. 这一发现为CF种群中病毒与宿主相互作用提供了洞察力.
科学领域:
- 呼吸道病毒感染 呼吸道病毒感染
- 免疫学 免疫学 免疫学
- 遗传学 遗传学 是一个
背景情况:
- 患有囊性纤维化 (pwCF) 的人面临呼吸道病毒感染的风险增加.
- 了解COVID-19对pwCF的影响对于管理他们的健康结果至关重要.
研究的目的:
- 为了研究COVID-19在患有囊性纤维化 (pwCF) 的人群中的后果,与非CF个体相比.
- 在囊性纤维化和SARS-CoV-2感染的背景下分析病毒与宿主细胞相互作用.
主要方法:
- 从CF和非CF个体收集了鼻口腔拭子,用于检测SARS-CoV-2.
- 用RNA测序来评估从鼻切片中的基因表达.
- COVID-19的严重程度是由住院治疗或增加氧气治疗需求来定义的.
主要成果:
- 包括171名患者 (65名pwCF,106名非CF);15.4%的pwCF和40.6%的非CF个体检测出SARS-CoV-2阳性.
- 主体转录组学显示CF样本中的核糖体基因下调,无论SARS-CoV-2状态如何.
- 在SARS-CoV-2感染后,干扰素信号在两组中都被上调,而在非感染CF样本中,运动毛细胞基因被上调.
结论:
- 在患有囊性纤维化 (CF) 的人群中,COVID-19的严重程度似乎不大于一般人群.
- 减少pwCF中的核糖体基因表达可能会减少蛋白质翻译,从而创造一个不太有利于病毒复制的环境.
- 结核病患者群体内的内在因素可能会保护他们免受COVID-19的严重后果.
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