介质蛋白和干扰素在基因治疗中介质层干细胞的基因治疗癌症
Urban Švajger1, Urška Kamenšek2
1Slovenian Institute for Transfusion Medicine, Department for Therapeutic Services, Šlajmerjeva Ulica 6, Ljubljana SI-1000, Slovenia; Faculty of Pharmacy, University of Ljubljana, Aškerčeva Cesta 7, Ljubljana SI-1000, Slovenia.
Cytokine & growth factor reviews
|March 20, 2024
概括
使用介质细胞干细胞 (MSCs) 进行局部输送介质蛋白 (ILs) 和干扰素 (IFNs),为增强癌症免疫疗法的疗效和减少全身毒性提供了一个有前途的策略.
科学领域:
- 免疫学 免疫学 免疫学
- 癌症生物学 癌症生物学
- 生物技术是生物技术.
背景情况:
- 细胞因子如介质蛋白 (IL) 和干扰素 (IFN) 调节瘤微环境和免疫反应.
- 在临床试验中,IL和IFN的全身用药显示出有限的疗效和显著的毒性.
- 正在探索本地交付策略,以改善治疗结果并最大限度地减少副作用.
研究的目的:
- 审查介质干细胞 (MSC) 作为IL和IFN在癌症治疗中的基于细胞的输送载体的潜力.
- 讨论基于MSC的基因疗法的工程技术.
- 为了突出这一治疗方法的未来进步.
主要方法:
- 对基于细胞因子的癌症免疫治疗的临床前和临床证据的审查.
- 讨论与基于细胞的药物输送相关的MSC属性 (例如可用性,扩张,免疫性,瘤定位).
- 探索基因疗法技术,为工程MSC提供IL和IFN.
主要成果:
- 由于MSC的可访问性,易扩张性和低免疫性,MSC非常适合基于细胞的全基性疗法.
- MSCs表现出固有的瘤向能力,促进治疗有效载荷的局部传递.
- 工程MSC用于IL和IFN输送,为增强抗瘤免疫力提供了一个可行的策略.
结论:
- 基于MSC的IL和IFN的输送是克服系统性细胞因子治疗局限性的有希望的方法.
- 通过MSCs进行有针对性的本地治疗可能会提高治疗疗效,同时减轻不良影响.
- 基于MSC的免疫治疗需要对工程技术和临床翻译进行进一步的研究.
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