可访问的染色体区域的动态和亚基因组主导在八形草的动态
Chao Fang1, Ning Jiang2,3,4, Scott J Teresi2,4
1Department of Plant Biology, Michigan State University, East Lansing, MI, 48824, USA.
Nature communications
|March 21, 2024
概括
章状草中亚基因组的主导地位与可访问的染色体区域 (ACR) 有关. 主导的亚基因组A保留了更多的ACR,特别是应激反应基因,这有助于其偏好的基因表达和稳定性.
科学领域:
- 植物基因组学 植物基因组学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 多聚体研究研究.
背景情况:
- 亚基因组主导性,偏好的基因保留和表达在全聚体中,是已知的现象.
- 驱动子基因组优势的潜在分子机制尚未得到充分理解.
研究的目的:
- 调查可访问的染色体区域 (ACRs) 在培养草中建立亚基因组优势中的作用.
- 为了绘制全基因组ACR图,并分析它们在八胞胎草的四个亚基因组 (A,B,C,D) 中的分布.
主要方法:
- 开发可访问的染色体区域 (ACR) 的全基因组地图,确定为MNase过敏位 (MHS).
- 在A,B,C和D亚基因组中对MHS分布和序列完整性的比较分析.
- 识别可转移的元素插入及其对MHS碎片化的影响.
主要成果:
- 主导亚基因组A表现出较多的MHSs和MHSs每基因与顺从亚基因组 (B,C,D) 相比.
- 亚基因组A显示,由于可移植元素插入,MHS相关的DNA序列损失减少,MHS碎片化减少.
- 参与应激反应的基因和相关的ACRs优先保留在亚基因组A.
结论:
- 保护基因及其相应的可访问色素区域 (ACR) 对于亚基因组主导性至关重要.
- 压力反应基因及其ACRs在亚基因组A中的优先保留有助于其在八形草中的支配地位.
相关概念视频
02:38Heterochromatin
12.6K
The extent of chromatin compaction can be studied by staining chromatin using specific DNA binding dyes. Under the microscope, the dense-compacted regions that take up more dye are called heterochromatin. Heterochromatin is further classified into two forms – constitutive heterochromatin and facultative heterochromatin.
Constitutive heterochromatin: It is a highly compact region of chromatin that is mostly concentrated in the centromere and telomere. Unlike euchromatin, the amino acid at...
Constitutive heterochromatin: It is a highly compact region of chromatin that is mostly concentrated in the centromere and telomere. Unlike euchromatin, the amino acid at...
12.6K
02:04Polytene Chromosomes
10.0K
Polytene chromosomes are giant interphase chromosomes with several DNA strands placed side by side. They were discovered in the year 1881 by Balbiani in salivary glands, intestine, muscles, malpighian tubules, and hypoderm of larvae Chironomus plumosus. Hence, these are also called "Salivary gland chromosomes." These are found in insects of the order Diptera and Collembola; in certain organs of mammals; and synergids, antipodes of flowering plants. Polytene chromosomes are also...
10.0K
02:32Position-effect Variegation
6.3K
In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
6.3K
03:17Inheritance of Chromatin Structures
6.2K
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
6.2K
02:35Chromatin Position Affects Gene Expression
23.3K
Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area.
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
23.3K
01:01Euchromatin
6.9K
The extent of chromatin compaction can be studied by staining chromatin using specific DNA binding dyes. Under the microscope, the dense-compacted regions take up more dye, appearing darker, while the less-compact areas take up less dye and appear lighter. Based on the compaction level, chromatins are classified into two primary forms – euchromatin and heterochromatin.
Euchromatin is the less dense region of the chromatin and stains lighter. Euchromatin contains histone H3 extensively...
Euchromatin is the less dense region of the chromatin and stains lighter. Euchromatin contains histone H3 extensively...
6.9K