暴露于空气污染可能会影响母乳寡糖的成分
Noopur C Naik1,2, Elizabeth A Holzhausen1, Bridget N Chalifour1
1Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
Scientific reports
|March 21, 2024
概括
环境空气污染暴露与人乳寡糖化合物 (HMO) 组成的变化有关,包括减少HMO多样性. 像PM2.5这样的特定污染物与某些有益的HMO水平的增加有关.
科学领域:
- 环境健康 环境健康
- 人类哺乳期哺乳期
- 新生儿营养新生儿营养
背景情况:
- 人类牛奶寡糖 (HMO) 对婴儿免疫力和发育至关重要.
- 影响HMO成分的环境因素尚不清楚.
- 环境空气污染 (AAP) 是一个日益严重的公共卫生问题.
研究的目的:
- 调查环境空气污染物 (AAP) 暴露与人乳寡糖化物 (HMO) 组成之间的关联.
- 分析PM2.5,PM10和NO2暴露对HMO多样性和特定HMO的影响.
主要方法:
- 从产后1个月的185名母亲收集了母乳样本.
- 评估AAP暴露 (PM2.5,PM10,NO2) 从怀孕到产后1个月.
- 使用多变量线性回归和主要成分分析 (PCA) 来检查关联.
主要成果:
- 暴露于AAP与减少HMO多样性有关.
- 暴露在PM2.5和PM10中显示出与3-fucosyllactose (3FL) 的积极关联.
- 暴露于PM2.5与增加的总HMO,可化HMO和2'-fucosyllactose (2'FL) 相关.
- PCA揭示了AAP暴露和整体HMO概况之间的关联.
- 另外五个HMO (LNFP I,LNFP II,DFLNT,LNH) 与AAP暴露有关.
结论:
- 这项研究提供了第一个证据,将环境空气污染暴露与母乳寡糖化合物成分的变化联系起来.
- 研究结果表明,AAP可能会影响母乳的保护性质.
- 需要进一步的纵向研究来了解AAP对母乳和婴儿健康的长期影响.
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