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Updated: May 11, 2026

Establishment and Optimization of a High Throughput Setup to Study Staphylococcus epidermidis and Mycobacterium marinum Infection as a Model for Drug Discovery
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增强可解释的SARS-CoV-2疫苗开发利用蜂群优化的Bi-LSTM,Bi-GRU模型和生物信息分析来提高疫苗的开发效率

Dilber Uzun Ozsahin1,2,3, Zubaida Said Ameen3,4, Abdurrahman Shuaibu Hassan5

  • 1Department of Medical Diagnostic Imaging, College of Health Science, University of Sharjah, Sharjah, UAE.

Scientific reports
|March 21, 2024
PubMed
概括

使用蜂群优化与双向长期短期记忆 (BCO-Bi-LSTM) 的新型深度学习方法有效预测疫苗开发的SARS-CoV-2表位. 这种方法加速了针对COVID-19的潜在疫苗候选人的识别.

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相关概念视频

Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
Vaccine Production01:23

Vaccine Production

Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...