婴儿便代谢物度的模式和幼儿的社会行为发展
Hannah E Laue1, Julia A Bauer2, Wimal Pathmasiri3,4
1Department of Epidemiology, Geisel School of Medicine at Dartmouth College, Hanover, NH, USA. Hannah.E.Laue@Dartmouth.edu.
Pediatric research
|March 21, 2024
概括
婴儿肠道细菌代谢物可能会影响社会行为. 在1岁儿童中,具有高乳酸和低短链脂肪酸的特定便代谢物概况与较少的自闭症相关行为有关.
科学领域:
- 微生物组研究的研究.
- 神经发育科学 神经发育科学
- 代谢学 代谢学 代谢学
背景情况:
- 肠道衍生代谢物是微生物和宿主共同代谢的产物.
- 这些代谢物可能为儿童神经发育的机制提供了洞察力.
- 以前关于肠-大脑相互作用和神经发育结果的研究已经产生了不一致的结果.
研究的目的:
- 调查婴儿便代谢物和随后的幼儿社会行为之间的关联.
- 探索潜在的肠道微生物对神经发育轨迹的贡献.
- 识别与幼儿时期社会行为相关的特定代谢物概况.
主要方法:
- 从6周和1岁的婴儿收集了便样本.
- 使用核磁共振光谱学进行了代谢分析.
- 用社会响应度量 (SRS-2) 来评估3岁儿童的社会行为.
- 统计方法包括单个代谢物分析,定量代谢物集丰富 (QEA) 和自我组织地图 (SOM).
主要成果:
- 没有任何单个便代谢物或6周或1岁儿童的代谢物组与使用单个代谢物或QEA方法的SRS-2得分相关.
- 自组织地图 (SOMs) 确定了6周大的4种便代谢物概况,与SRS-2得分无关.
- 在1岁儿童中,SOM识别的12种代谢物概况中的一个与显著较低的SRS-2得分相关,表明自闭症相关行为较少.
- 这种特异性特征是乳酸度较高,短链脂肪酸度较低.
结论:
- 一岁婴儿的特定便代谢物概况与随后的社会行为有关.
- 鉴定出的高乳酸和低短链脂肪酸的特征表明肠道微生物代谢与神经行为结果之间存在潜在联系.
- 应用SOMs,一种机器学习算法,在发现代谢物模式和社会行为之间的新兴关联方面被证明是有效的.
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