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Updated: Jun 30, 2025

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在多种乳腺癌模型中,E-cadherin与EGFR相互作用,导致ERK的过激活

Gabriella C Russo1,2, Ashleigh J Crawford1,2, David Clark3

  • 1Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 N Charles St, Baltimore, MD, 21218, USA.

Oncogene
|March 21, 2024
PubMed
概括

以前被认为可以抑制瘤的E-cadherin实际上通过与EGFR相互作用来驱动乳腺癌的扩散. 抑制MEK激酶有效地减少了E-cadherin阳性乳腺癌的瘤生长和转移.

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