增加阻塞性睡眠呼吸暂停风险与韩国成年人的白膜尿有关:横截面分析
Suk Won Chang1,2, Ju Wan Kang3
1Department of Otorhinolaryngology, Jeju National University College of Medicine, Jeju, Korea.
Scientific reports
|March 21, 2024
概括
这项研究发现,通过STOP-BANG问卷识别的阻塞性睡眠呼吸暂停 (OSA) 的高风险与韩国成年人的白色素尿和白色素尿增加之间存在显著联系. 对于患有OSA高风险的人士,建议对功能进行评估.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 肺部病理学 肺部病理学
- 睡眠医学 睡眠医学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 与白膜尿有关,但与STOP-BANG问卷等OSA风险查工具的关系尚未得到充分研究.
- 微专尿和蛋白尿是损伤的指标.
研究的目的:
- 在韩国成年人中,使用STOP-BANG问卷评估微专尿和阻塞性睡眠呼吸暂停 (OSA) 风险之间的关联.
- 澄清OSA风险与功能障碍标志物之间的关系.
主要方法:
- 在2019-2020年韩国国家健康和营养检查调查中,对7478名40岁以上的韩国成年人进行了横截面研究.
- 使用STOP-BANG问卷评估了OSA风险.
- 测量了尿中的白蛋白/肌素比率 (ACR) 和蛋白尿,以评估功能.
主要成果:
- 与低OSA风险组相比,高OSA风险组的ACR平均值显著更高 (36.8 ± 172.2对17.7 ± 82.5,P < 0.001).
- 在高OSA风险组中观察到更高比例的微专尿 (30 ≤ACR < 300 mg/g) 和大专尿 (ACR > 300 mg/g) 患者 (P < 0.001).
- 多变量分析证实了高OSA风险和微专尿 (OR 1.279),大专尿 (OR 1.684) 和蛋白尿 (OR 1.355) 之间的显著相关性.
结论:
- 在韩国成年人中,高OSA风险与白色素尿和蛋白尿的存在之间存在显著的相关性.
- 对于被确定为OSA高风险的人来说,对功能评估是有必要的.
- 在高风险患者中,建议通过多睡眠学 (PSG) 及时诊断OSA,并随后进行治疗.
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