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在混合结缔组织疾病患者中进行皮毛细分镜检查

Sylwia Ornowska¹, Mariusz Wudarski², Ewa Dziewięcka³

¹Department of Connective Tissue Diseases, National Institute of Geriatrics, Rheumatology and Rehabilitation, ul. Spartańska 1, 02-637, Warsaw, Poland. sylwia.ornowska@spartanska.pl.

Clinical rheumatology

|March 21, 2024

概括

爪毛细膜镜检查 (NFC) 显示了混合连接组织疾病 (MCTD) 患者的特征异常. 毛细管密度降低和NFC上类似于硬质皮肤的模式与特定的临床特征相关,如硬质结节症和肺动脉高血压.

科学领域:

类风湿病学类风湿病学
皮肤病学皮肤病学
血管生物学血管生物学

背景情况:

混合结合组织疾病 (MCTD) 呈现出SLE,SSc,DM/PM和RA的重叠症状.
爪毛细血管镜 (NFC) 是一种非侵入性的风湿性疾病诊断工具,检查指甲轴毛细血管.

研究的目的:

在MCTD患者中识别特征性NFC异常.
为了将NFC病变类型与MCTD中特定器官参与相关联.

主要方法:

对43名MCTD患者的临床数据和NFC模式的分析.
毛细管学图像的分类,分为类似于硬质瘤 (类似于SD) 的模式,非特异性病变或正常.
评估临床标准与毛细管镜检测结果之间的关系.

主要成果:

在46.51%的MCTD患者中观察到一种类似于硬化皮质的模式,通常是"早期"的模式.
与对照组相比,MCTD患者的毛细血管显著增加,分支和扩张,毛细血管密度减少.
减少血管数量,无血管区域,和与硬化症相关联的SD类模式.
分支血管和可见的亚毛细血管与肺动脉高血压 (PAH) 有关.

结论:

在MCTD患者中,NFC异常很常见,使得毛细管镜检查成为一种有价值的诊断检查.
减少毛细血管密度是MCTD诊断的重要预测因素.
特定的NFC发现与临床表现相关,例如在MCTD中出现硬化症和PAH.

关键词:

结合性组织疾病结合性组织疾病显微镜的使用方法微血管损伤的发生.脊髓硬化症是什么脊髓硬化症是什么

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