相关实验视频
Updated: Jun 30, 2025

07:21
Generation of Naïve Blastoderm Explants from Zebrafish Embryos
Published on: July 30, 2021
3.4K
大脑是如何从表皮质形成的:节点不是组织者
1Osaka University, Suita, Osaka, Japan.
Results and problems in cell differentiation
|March 21, 2024
概括
鸟类胚胎研究揭示了大脑发育机制. 表皮质细胞聚集在前半皮上,形成大脑原体,没有直接的节点参与,推进发育生物学见解.
科学领域:
- 发育生物学是发展生物学.
- 神经科学是一个神经科学.
- 胚胎学 胚胎学
背景情况:
- 由于可访问的培养和操纵,鸟类胚胎是发育生物学中的关键模型.
- 缺乏对大脑和头部发育规则的系统研究.
研究的目的:
- 系统地研究鸟类胚胎中大脑和头部发育的调节机制.
- 识别参与早期大脑形成的新型细胞事件和途径.
主要方法:
- 开发了一种用绿色光蛋白随机标记表皮质细胞的技术.
- 采用光标记节点或前端介质皮的移植.
- 进行了18小时的实时成像,记录大脑发育期间的细胞事件.
主要成果:
- 确定所有前端表皮质细胞都能形成脑组织.
- 证明了表皮质细胞聚集在前端介质皮上,以启动大脑原始形成.
- 排除了节点在大脑发育中的直接参与,并重新解释了古典数据.
结论:
- 在前半膜体上的表皮细胞聚集是鸟类大脑启动的关键.
- 大脑发育过程独立于直接的节点信号传输.
- 这项研究为了解早期神经发育提供了新的模型.
相关概念视频
Gastrulation
57.4K
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
57.4K
Neurulation
41.9K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
41.9K
Zygotic Development And Stem Cell Formation
5.2K
The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
5.2K
Development of Blood Vessels
582
The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
582
Cleavage and Blastulation
45.2K
After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.
45.2K
Hematopoiesis
5.3K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
5.3K

