对待异质治疗效应的不同试验的1型和2型错误率进行比较
Steffen Nestler1, Marie Salditt2
1University of Münster, Institut für Psychologie, Fliednerstr. 21, 48149, Münster, Germany. steffen.nestler@uni-muenster.de.
Behavior research methods
|March 21, 2024
概括
研究人员应在临床试验中使用随机化测试来检测治疗效果的异质性. 目前的方法在小到中等样本中缺乏力量,需要更大的样本大小来进行准确的分析.
科学领域:
- 心理学 心理学 心理学
- 生物统计学 生物统计学
- 临床试验 临床试验
背景情况:
- 心理学家在随机对照试验中研究治疗效果的变化.
- 因果推理文献提供了治疗效果异质性的各种测试.
研究的目的:
- 在随机对照试验中评估不同异质性测试的性能.
- 检查影响测试性能的因素,包括异质水平,分布,样本大小和共变量.
主要方法:
- 模拟研究检查治疗效果异质性的多个统计测试.
- 变化的参数:异质性程度,分布类型,样本大小和共同变量存在.
主要成果:
- 推随机化测试,以最佳控制1型错误.
- 所有经过测试的方法都表现出较低的统计能力,样本规模小到中等,即使具有相当大的异质性.
- 目前对治疗效果异质性的测试需要比通常使用的样本大小大得多.
结论:
- 随机化试验为评估治疗效果异质性提供了优越的1型错误控制.
- 现有的异质性测试在常见的研究样本大小方面不足.
- 在测试治疗效果异质性时,未来的研究应该考虑更大的样本大小.
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