在全球范围内,蝙蝠为宿主的P1/致病性Leptospira物种的遗传多样性
J Manuel Matiz-González1,2, Jesús A Ballesteros-Ballesteros1, María Hernández1
1Grupo de Enfermedades Infecciosas, Departamento de Microbiología, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá, Colombia.
Zoonoses and public health
|March 21, 2024
概括
蝙蝠携带多种不同的Leptospira细菌,主要是在致病性P1类中. 这项研究揭示了蝙蝠宿主Leptospira的显著遗传多样性,突出了它们作为这些动物传染病原体的水库的作用.
科学领域:
- 微生物学 微生物学
- 动物传播疾病 动物传播疾病
- 哺乳动物学 哺乳动物学
背景情况:
- 蝙蝠是已知的动物传染病原体的储存库,包括Leptospira物种.
- 莱普托斯皮拉被分为致病性,中间性和性群体,致病性物种主要在P1类.
- 虽然Leptospira在蝙蝠中的存在已被全球记录,但它们的遗传多样性在很大程度上仍未知.
研究的目的:
- 为了研究全球蝙蝠藏的LeptoSpira物种的遗传多样性.
- 分析蝙蝠衍生的Leptospira序列的遗传关系.
主要方法:
- 在四个数据库中进行了科学文献的系统审查.
- 来自蝙蝠的Leptospira 16S rRNA基因序列从GenBank.被检索出来.
- 对获取的序列进行了遗传学分析,并与参考Leptospira物种一起进行了分析.
主要成果:
- 总共分析了来自14个国家的55种蝙蝠种的418个Leptospira 16SrRNA序列.
- 绝大多数 (417/418) 序列属于P1/致病类,其中一个序列属于P2/中间类.
- 确定了六个主要的P1/致病性LeptoSpira分类,其中三个分类仅包含来自蝙蝠的序列.
结论:
- 蝙蝠拥有相当大的Leptospira spp.的遗传多样性. 在P1/病原性分类中.
- 一些与蝙蝠相关的LeptoSpira菌株与已知在人类中引起LeptoSpirosis的物种密切相关.
- 这些发现强调了蝙蝠作为病原性LeptoSpira的储库的重要性,并有助于理解全球的LeptoSpiral多样性.
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