种族/民族对三模治疗后癌症特异性死亡率的影响
Mario de Angelis1,2,3, Andrea Baudo4,5, Carolin Siech4,6
1Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montréal Health Center, Montréal, Québec, Canada. deangelis.mario@hsr.it.
Journal of racial and ethnic health disparities
|March 21, 2024
概括
对于膀癌的三模治疗 (TMT) 使用和结果因种族而异. 西班牙裔人获得TMT的机会较低,而非裔美国人面临更糟糕的生存率,亚洲/太平洋岛民在TMT后的生存率更好.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 健康差异 在健康上的差异
背景情况:
- 三式治疗 (TMT) 是一种经过验证的膀节约治疗,用于尿道膀受器官限制的泌尿道癌 (OC UCUB).
- 现有的研究还没有充分探讨TMT使用中的种族/民族差异或它对癌症特异性死亡率 (CSM) 的影响.
研究的目的:
- 调查基于种族/种族的TMT与激进囊切除术 (RC) 使用的差异.
- 分析不同种族/种族群体中接受TMT治疗的患者癌症特异性死亡率 (CSM).
主要方法:
- 使用了监测,流行病学和最终结果 (SEER) 数据库 (2004-2020年) 对OC UCUB (cT2N0M0) 患者.
- 随着时间的推移,TMT与RC利用趋势进行了比较.
- 进行了生存分析,包括卡普兰-梅尔图和多变量考克斯回归,以根据种族/种族来评估TMT治疗患者的CSM.
主要成果:
- 西班牙裔患者的TMT利用率最低 (17.9%).
- 白人美国人和亚洲/太平洋岛民的TMT使用量随着时间的推移而增加,但其他群体的使用量并没有增加.
- 卡普兰-梅尔分析显示了中位数CSM的显著差异:亚洲/太平洋岛民的生存率最高,其次是非洲裔美国人,西班牙裔美国人和白人美国人.
- 多变量考克斯回归发现,与白人相比,非洲裔美国人有更糟糕的CSM (HR: 1.20),亚洲/太平洋岛民有更好的CSM (HR: 0.75).
结论:
- 种族/种族显著影响了获得TMT的机会,在西班牙裔人口中观察到的比例较低.
- 在TMT后的生存结果因种族/种族而异,亚洲/太平洋岛民的生存率有所改善,非裔美国人的生存率更差.
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