相关实验视频

Updated: Jun 30, 2025

Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy

Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy

Published on: January 12, 2019

杜申肌力发育不良的儿童和青少年的神经认知功能:系统性审查和元分析

Jayne Gregg¹, Colin Wilson², David Curran³

¹Regional Neurosciences, Royal Victoria Hospital.

The Clinical neuropsychologist

|March 21, 2024

概括

患有杜申肌力发育不良症 (DMD) 的儿童表现出神经认知缺陷,在全尺度智商,性能智商,口头智商和工作记忆中表现出大约一个标准偏差低于非临床规范. 受感词汇的分数在正常范围内.

科学领域:

神经科学是一个神经科学.
儿科儿科儿科
遗传学遗传学是一个

背景情况:

杜氏肌肉发育不良 (DMD) 是一种严重的遗传疾病,主要影响肌肉组织.
与其生理效应相比,DMD的神经认知方面的理解较少.
缺乏对患有DMD儿童神经认知特征的系统审查.

研究的目的:

对患有DMD的儿童和青少年的神经认知特征进行系统审查和元分析.
综合特定神经认知领域的发现,包括智商和工作记忆.
识别有关DMD神经认知的文献上的空白.

主要方法:

在五个数据库 (EMBASE,Medline,PsycInfo,Scopus,Web of Science) 和灰色文学中进行系统的文献搜索.
包括报告具有可比性神经认知结果的研究,包括全尺度智商 (FSIQ),口头智商 (VIQ),表现智商 (PIQ),工作记忆指数 (WMI) 和感受词汇 (PPVT).
来自38项符合条件的研究的数据的元分析.

主要成果:

患有DMD的儿童在FSIQ,PIQ,VIQ和WMI的非临床规范下大约1SD的表现.
通过皮博迪图片口语测试 (PPVT) 测量的感受性词汇分数处于非临床规范范围内.
包括的研究质量中等至高,具有显著的异质性,但没有出版偏差.

结论:

患有DMD的儿童在一般智力功能和工作记忆方面表现出显著的神经认知缺陷.
神经认知特征表明了特定的弱点,与接受性词汇能力不同.
建议对PPVT得分与DMD中更广泛的语言智力构造的可互换性保持谨慎.

关键词:

杜申尼肌肉发育不良症杜申尼肌肉发育不良症这是一个元分析.皮博迪影像口头测试语言测试系统性审查系统性审查切塞尔情报规模是什么意思

更多相关视频

Assessing Functional Performance in the Mdx Mouse Model

Assessing Functional Performance in the Mdx Mouse Model

Published on: March 27, 2014

A Simple and Low-cost Assay for Measuring Ambulation in Mouse Models of Muscular Dystrophy

A Simple and Low-cost Assay for Measuring Ambulation in Mouse Models of Muscular Dystrophy

Published on: December 29, 2017

相关概念视频

Satellite Stem Cells and Muscular Dystrophy

Satellite Stem Cells and Muscular Dystrophy

Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...

Disorders of the Skeletal Muscle

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...

Information Processing Approach

Information Processing Approach

The information-processing theory of cognitive development centers on fundamental mental processes, including attention, memory, and problem-solving skills. Researchers in this field examine how cognitive abilities, such as working memory, evolve and influence children's overall development. Studies indicate that children with stronger working memory tend to excel in reading comprehension, math, and problem-solving compared to peers with less efficient memory skills. Low working memory is...