代谢综合征成分的种族差异及其与肠道微生物群的关联:HELIUS研究
Manon Balvers1, Marcus de Goffau1,2,3, Natal van Riel1
1Department of Internal and Vascular Medicine, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Genome medicine
|March 21, 2024
概括
代谢综合征 (MetS) 和肠道微生物群因种族而异. 肠道微生物和MetS组件之间的关联既是普遍的,也是特定于种族的,这表明需要个性化的方法来定义和治疗MetS.
科学领域:
- 微生物组研究的研究.
- 代谢健康 代谢健康
- 人口健康 人口健康
背景情况:
- 代谢综合征 (MetS) 的患病率和肠道微生物群组成在各个族群之间存在差异.
- 种族,肠道微生物群和MetS组件之间的相互作用在很大程度上仍未被探索.
- 了解这些关系对于有针对性的健康干预至关重要.
研究的目的:
- 调查HELIUS队伍中不同种族的MetS及其组件的发生情况.
- 确定肠道微生物群组成和MetS结果之间的种族特异关联.
- 评估肠道微生物群对跨种族的单个MetS组件的相对贡献.
主要方法:
- 分析了HELIUS研究中的16,209名未接受过治疗的参与者,代表荷兰人,非洲苏里南人,南亚苏里南人,加纳人,土耳其人和摩洛哥人.
- 在3443名参与者的子集中分析了肠道微生物组组成 (16S rRNA基因测序).
- 使用线性和逻辑回归模型,将肠道微生物群与MetS结果联系起来,考虑特定种族因素.
主要成果:
- 跨种族观察到MetS组件的不同患病率,血压 (加纳人) 和脂质配置文件 (南亚苏里南人,土耳其人) 的特定模式.
- 种族独立的协会显示,更高的α多样性和特定细菌网络 (RCM) 与更好的MetS结果相关.
- 显著的种族特异性关联出现了,特别是在α-多样性和RCM网络中,加纳人显著例外,显示出与高血压的积极关联.
结论:
- MetS特征在各族群中表现出显著的异质性.
- 肠道微生物群和MetS结果之间存在着共同和独特的关联,根据种族而异.
- 对于MetS的定义和治疗,建议采用个性化的方法,而不是一种适合所有人的方法,考虑到肠道微生物群的作用.
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