童年逆境的特点是神经发育期间个体的大脑模式的异质性
Rajan Kashyap1, Bharath Holla2, Sagarika Bhattacharjee3
1Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bengaluru, India.
Psychological medicine
|March 21, 2024
概括
童年逆境,特别是虐待,在神经发育过程中显著影响默认模式网络 (DMN),导致异常的大脑模式. 这种灵活性可能是一种具有长期后果的应对机制.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 脑部成像 脑部成像
背景情况:
- 神经发育轨迹受到各种因素的影响.
- 识别对大脑发育的关键影响对于理解典型与非典型发育至关重要.
研究的目的:
- 用功能性MRI数据调查逆境对神经发育的影响.
- 确定区分典型与非典型神经发育的因素.
主要方法:
- 应用动态模式分解 (DMD) 和不相似度最大化算法,对来自987名受试者 (6-23岁) 的静止状态fMRI数据进行了应用.
- 将受试者分为典型的 (同质的DMD) 和非典型的 (异质的DMD) 发育组.
主要成果:
- 在典型和非典型组之间的默认模式网络 (DMN) 中发现了DMD模式的显著差异.
- 非典型的发育与更高的暴露于逆境和虐待有关.
- 在非典型组中观察到逆境和DMN动态之间的年龄相关性.
结论:
- 逆境,特别是滥用,深刻影响DMN的发展,阻碍形成一个连贯的系统.
- 在非典型的发育中,DMN的适应能力可以作为补偿机制,但可以损害正常功能,并产生持久的心理影响.
更多相关视频
相关概念视频
Attention-Deficit/Hyperactivity Disorder
59
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
59
Neuroplasticity
344
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
344
Disorders of the Nervous Tissue
1.3K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
1.3K
Human Genetics
566
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
566
Biological Causes of Schizophrenia
57
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
57
Language and Cognition
345
Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
345


