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一个高密度的键锁定策略,用于构建无异性高强度的基于凝的阴茎替代物

Qian Zhang¹, Xuxuan Yang¹, Kuan Wang¹

¹School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin, 300350, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|March 21, 2024

概括

一种新的高密度键锁定策略可以产生强的,异性质的水凝. 这些先进的材料模仿自然组织,在动物模型中显示了骨关节炎治疗的前景.

科学领域:

生物材料科学生物材料科学
聚合物化学聚合物化学
组织工程是组织工程.

背景情况:

模仿异型特征对于制造负荷承载的人造软组织,如阴道肌,至关重要.
现有的水凝往往缺乏这种应用所需的机械强度和异构性质.

研究的目的:

开发一种用于制造高强度异构型水凝的新策略.
评估这些水凝作为骨关节炎治疗的阴茎支架的潜力.

主要方法:

采用高密度键锁定 (HDHBL) 策略,使用聚N-烯半化 (PNASC) 水凝.
该过程涉及预加载PNASC水凝与键破解剂,然后进行水交换以重新建立键和导向分子链.
使用3D打印和HDHBL策略制造了一个阴茎支架,然后植入子膝关节.

主要成果:

制造出来的异性质水凝表现出优异的机械性能,包括拉伸强度>9 MPa,Young模量>120 MPa,疲劳值>1900 J/m2.
在12周的时间里,异型阴茎支架表现出一种冠状动脉保护作用,并改善了子膝关节关节的骨关节炎进展.
在水凝中创建定向微结构时,HDHBL策略被证明是有效的.

结论:

HDHBL 战略成功地生产了适合承载应用的异构型,高强度的水凝.
使用这种方法制造的无异型阴茎支架显示了对骨关节炎的治疗潜力.
这种技术扩大了异型聚合物水凝在各种领域的适用性.

关键词:

通过3D打印打印3D打印.这是一种无otropic 水凝.通过键结合,形成键.阴茎的替代品阴茎的替代品预装载预装载

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