用于治疗COVID-19的艾弗梅克丁:系统性审查和元分析
Zhilong Song1, Senyuan Shi2, Yongli Zhang3
1School of Public Health, Xiamen University, Fujian, China.
Heliyon
|March 21, 2024
概括
在COVID-19患者中使用IVM对死亡率或病毒清除没有影响. 然而,IVM与减少机械通风需求和较少的不良事件有关,这表明临床使用要谨慎.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 尽管广泛使用,但对治疗COVID-19的IVM疗效仍然存在争议.
- 在COVID-19患者中,系统评估与IVM相关的临床结果至关重要.
研究的目的:
- 在被诊断为COVID-19的患者中系统地审查和评估ivermectin的临床结果.
- 评估IVM对死亡率,机械呼吸,病毒清除和不良事件的影响.
主要方法:
- 在PubMed,EMBASE,科学网,Scopus,Cochrane图书馆,medRxiv和bioRxiv进行了系统的文献搜索,截至2023年6月22日.
- 这项分析包括了33项随机对照试验 (RCT),涉及10,489名患者.
- 偏差风险和证据质量使用Revman 5.4.4进行评估.
主要成果:
- 在ivermectin和对照组之间没有观察到任何原因死亡率或PCR负转换的显著差异.
- 在ivermectin组中,机械通风的需求显著减少 (RR 0.67,95% CI 0.47-0.96).
- 艾弗梅克丁的使用也与不良事件的显著减少有关 (RR 0.87,95% CI 0.80-0.95).
结论:
- 在COVID-19患者中,IVERMECTIN治疗没有显著影响死亡率或病毒清除.
- 艾弗梅克丁可以减少机械通风的需要和COVID-19患者不良事件的发生.
- 临床医生可能会考虑在COVID-19患者中谨慎使用ivermectin,特别是在没有优质替代品的情况下.
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