运动训练通过降低2型糖尿病大鼠的fetuin-A,氧化应激和炎症来改善糖尿病损伤
Shadan Saberi1, Majid Askaripour2, Mohammad Khaksari3
1Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Heliyon
|March 21, 2024
概括
高强度间歇训练 (HIIT) 可以通过减少炎症和改善抗氧化剂防御来帮助降低糖尿病大鼠的损伤. 这种运动干预措施在治疗糖尿病病方面表现有前途.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 内分泌学 在内分泌学.
- 运动生理学 运动生理学
背景情况:
- 糖尿病病 (DKD) 是末期病和心血管死亡的主要原因.
- 了解缓解DKD的干预措施对于公共卫生至关重要.
研究的目的:
- 研究一项为期八周的高强度间歇训练 (HIIT) 计划对2型糖尿病大鼠模型中的损伤的影响.
- 评估HIIT对炎症,氧化应激和与糖尿病病相关的特定生物标志物的影响.
主要方法:
- 雄性Wistar大鼠被分为四组:对照组,糖尿病控制组,运动组和带运动的糖尿病组.
- 使用高脂肪饮食和链毒素 (STZ) 诱导糖尿病.
- 运动组进行了8周的HIIT;然后分析脏和血清参数.
主要成果:
- 糖尿病导致严重的损伤,炎症 (TNF-α,TGF-β,IL-6的增加;IL-10的减少),氧化应激 (MDA的增加,GPx,甲酶,SOD的减少),以及升高的fetuin-A和KIM-1.
- 与糖尿病控制组 (DC) 相比,糖尿病大鼠 (D+EX组) 的HIIT干预显著改善了这些糖尿病诱导的病理和生化变化.
- 具体来说,HIIT减少了淋巴结核硬化,白蛋白尿,改善了功能标志物.
结论:
- 高强度间歇训练 (HIIT) 有效地减轻2型糖尿病引起的损伤.
- HIIT可以缓解脏炎症,降低血清Fetuin-A水平,增强糖尿病脏病患者的抗氧化能力.
- 这项研究支持HIIT作为一种节省时间和有效的干预措施,用于管理糖尿病病.
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