城市固体废物转移站的液在Wistar老鼠中产生神经毒性
Torres-González Omar Ricardo1, Flores-Soto Mario Eduardo2, Tejeda-Martínez Aldo Rafael2
1Unidad de Biotecnología Médica y Farmacéutica, Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco (CIATEJ), Mexico.
Toxicology reports
|March 21, 2024
概括
城市固体废物水中含有重金属,可能会伤害水生生物和人类. 这项研究表明,大鼠暴露在液中会导致大脑损伤,这表明受污染的水可能带来神经系统风险.
科学领域:
- 环境毒理学环境毒理学
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 城市固体废弃物水由于异生菌污染物造成环境风险.
- 之前的研究发现,城市固体废物转移站 (USWTS) 水中的重金属超过了安全标准.
研究的目的:
- 在雄性Wistar大鼠中研究长期口服暴露于USWTS液的神经毒性作用.
- 评估液污染物对大脑组织和神经元完整性的影响.
主要方法:
- 雄性Wistar大鼠在5%和25% (v/v) 的度下口服液,持续时间为次慢性期.
- 分析了质标记物的免疫活性 (GFAP,Iba-1),caspase-3的表达,以及NeuN蛋白的表达.
- 评估了前额叶皮层的神经损失.
主要成果:
- 浸出物暴露改变了质标记体的免疫反应活性 (GFAP,Iba-1).
- 观察到卡斯巴-3 (亡标记物) 的表达增加和NeuN (神经元标记物) 的减少.
- 前额叶皮层中显著的神经元损失是由液暴露引起的.
结论:
- 城市固体废物中的重金属可诱导神经毒性和神经元损失哺乳动物.
- 污染的地表和地下水源对野生动物和人类造成神经系统问题的风险.
- 这项研究强调,迫切需要有效的水管理,以保护水资源和公共卫生.
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