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Updated: Jun 30, 2025

Dissecting Cell-Autonomous Function of Fragile X Mental Retardation Protein in an Auditory Circuit by In Ovo Electroporation
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Published on: July 6, 2022

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翻译调制器ISRIB减轻了脆弱X综合征中的突触和行为表型

Rochelle L Coulson1, Valentina Frattini1, Caitlin E Moyer2

  • 1Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA.

iScience
|March 21, 2024
PubMed
概括

脆弱X综合征 (FXS) 治疗显示出有希望的结果. 通过集成应激反应抑制剂 (ISRIB) 准蛋白质合成,在小鼠模型中改善了突触功能和社会行为,提供了新的治疗途径.

关键词:
细胞生物学 细胞生物学细胞神经科学 细胞神经科学模型生物模型生物.分子神经科学分子神经科学小分子分子 小分子分子

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