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Updated: Jun 30, 2025

Performing Human Skeletal Muscle Xenografts in Immunodeficient Mice
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工程 FSHD 突变导致 D4Z4 异染色素破坏和前 DUX4 网络激活

Xiangduo Kong1, Nam Viet Nguyen1, Yumeng Li1

  • 1Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA, USA.

iScience
|March 21, 2024
PubMed
概括

面肌肌缩症 (FSHD) 的发病包括D4Z4收缩和DUX4上调. 像SMCHD1这样的疾病修饰剂影响DUX4的激活,揭示了FSHD发展的关键见解.

关键词:
细胞生物学 细胞生物学基因组学就是基因组学.分子生物学分子生物学基因调节的分子机制

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