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患有COVID-19的住院儿童的凝血概况:儿科年龄依赖及其对长期COVID发育的影响

Oksana Boyarchuk¹, Vita Perestiuk¹, Tetyana Kosovska¹

¹Department of Children's Diseases and Pediatric Surgery, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine.

Frontiers in immunology

|March 21, 2024

概括

儿童的COVID-19可能会导致凝血异常,与长期COVID发育相关的异常前热血素时间 (PT). 需要对儿科凝血概况进行进一步的研究.

科学领域:

儿科医学儿科医学
血液学血液学血液学
传染性疾病传染性疾病

背景情况:

COVID-19与内皮病变和免疫血栓形成有关.
持续的内皮病变和凝结能力可能会导致长期的COVID发展.
了解儿科COVID-19中的凝血概况对于长期COVID研究至关重要.

研究的目的:

为了研究小儿COVID-19患者的凝血概况.
确定凝血参数在长期COVID发展中的作用.
分析COVID-19儿童的依赖年龄的凝血变化.

主要方法:

对190名儿科COVID-19患者进行的前性单中心队列研究.
凝血概况分析,包括激活的部分血栓塑时间和前血栓时间.
根据世卫组织的定义,对长期COVID症状进行后续监测.

主要成果:

94.5%的COVID-19儿童显示出凝血特征异常,随年龄而异.
激活的部分血栓塑时间 (69.1%) 和前血栓时间 (39.8%) 的增加是常见的.
异常的前列血时间 (PT) 是儿童长期COVID的重要危险因素 (OR 2.06).

结论:

凝血异常在儿科COVID-19中很普遍,并且取决于年龄.
异常PT,女性性别和并发症是长期COVID的潜在风险因素.
需要对儿科凝血进行进一步的研究,以了解血栓炎症和长期COVID.

关键词:

在 COVID-19 疫情中,这是一种SARS-CoV-2感染.孩子们的孩子们的孩子们的孩子们凝固的概况凝固的概况长时间的COVID.有关风险因素的风险因素.

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