人类牛奶寡糖分别支持肠道屏障完整性,并增强Th1和Th17细胞效应因子反应in vitro
Erik Juncker Boll1, Daniel Villalba Lopez1, Mandy Terne1
1Chr. Hansen A/S, Applied HMOs, Hoersholm, Denmark.
Frontiers in immunology
|March 21, 2024
概括
人类牛奶寡糖 (HMO) 对婴儿肠道健康有结构依赖的影响. 化HMO (3'SL和6'SL) 增强免疫反应,而化和中性HMO增强肠道屏障.
科学领域:
- 人类免疫学 人类免疫学
- 胃肠病学 胃肠病学
- 营养科学 营养科学
背景情况:
- 人类牛奶寡糖 (HMO) 对婴儿肠道成熟和免疫系统发育至关重要.
- 个人HMO及其结构变异在调节肠道环境中的特定作用仍然不完全理解.
研究的目的:
- 研究不同类型的HMO对肠道上皮细胞和免疫细胞的结构依赖作用.
- 为了确定福科西化,化和中性非福科西化HMO如何影响肠道屏障完整性和免疫细胞反应.
主要方法:
- 评估了特定HMO (2'FL,3FL,3'SL,6'SL,LNT,LNT2) 对肠道屏障功能的影响.
- 由HMO刺激的肠道上皮细胞的测量化学分泌物.
- 分析了由脂聚糖 (LPS) 激活的树突细胞 (DCs),M1巨细胞 (MØs) 和与暴露于HMO的CD4+T细胞共同培养的细胞因子概况.
主要成果:
- 富可化和中性非富可化HMOs改善并保护了肠道屏障的完整性,但具有最小的免疫调节作用.
- 化HMOs (3'SL,6'SL) 显著增强了肠道上皮细胞的化学分泌.
- 化HMO调节了免疫细胞的细胞因子释放,促进了Th1和Th17反应,同时抑制了Th2反应.
结论:
- HMO 具有结构特异性的功能,影响肠道屏障和免疫系统.
- 化HMO在塑造婴儿免疫反应方面发挥着关键作用,支持有益的Th1/Th17特征.
- 这些发现强调了HMO结构在为婴儿提供健康益处方面的重要性,并可能在整个生命中发挥作用.
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