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Updated: Jun 30, 2025

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miR-539-5p针对BMP2,通过TGF-β/Smads/MAPK调节B细胞急性淋巴细胞白血病中的Treg激活

Qingkai Dai1,2, Rui Shi1,2, Ge Zhang1,2

  • 1Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.

Experimental biology and medicine (Maywood, N.J.)
|March 21, 2024
PubMed
概括

微RNA-539-5p在B细胞急性淋巴细胞白血病 (B-ALL) 中表达不充分,通过增加BMP2促进瘤生长. 然后,这种BMP2激活调节性T细胞 (Tregs),推动B-ALL的进展.

关键词:
B细胞急性淋巴细胞白血病.这就是BMP2的原因.在TGF-β的基础上.这就是Treg Treg.在 miR-539-5p 中使用.

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